Pharvaris presents clinical and non-clinical data supporting HAE development program at the 2024 ACAAI Annual Scientific Meeting

Pharvaris announced data from seven posters that will be presented at the 2024 Annual Scientific Meeting of the American College of Allergy, Asthma & Immunology (ACAAI).

Pharvaris mourns our distinguished colleague, Prof. Marcus Maurer, who passed away during the development and finalization of these posters.

Peng Lu MD PhD, Chief Medical Officer of Pharvaris, said: “The totality of data supporting deucrictibant’s potential best-in-class profile in both prophylaxis and on-demand remains consistent and provides compelling validation for its continued clinical development. The data presented at ACAAI continue to clinically derisk deucrictibant and contribute to excitement for deucrictibant to become a preferred therapy in HAE.”

The CHAPTER-1 Phase 2 data provide proof of the efficacy and safety of deucrictibant for the prevention of HAE attacks and support its further development as a potential prophylactic therapy for HAE, which will be presented by H James Wedner MD. Specifically, Dr Wedner explores deucrictibant’s ability to decrease the median percentage of days with symptoms to 1.7% (40 mg/day) from 14.6% (placebo).

Results of the ongoing CHAPTER-1 open-label extension study provide further evidence on the long-term safety and efficacy of deucrictibant for prevention of HAE attacks and support further development of deucrictibant as a potential prophylactic therapy for HAE, which will be presented by John Anderson MD. Importantly, approximately 80% of participants achieved at least a 90% reduction in attack rate relative to the study baseline (as studied in the randomized clinical trial).

Pharvaris’ confidence in the design of both the prophylactic and on-demand Phase 2 and Phase 3 studies is supported by nonclinical data in the bradykinin (BK) challenge model in non-human primates (NHPs). The pharmacokinetic and pharmacodynamic (PK/PD) profile of deucrictibant in the NHP BK challenge was shown to be predictive of the human PK/PD in the human BK challenge, as presented by Juan Bravo PhD. Successful predictions of efficacious dosing of deucrictibant in humans were obtained following in-house modeling of nonclinical. in line with the Phase 2 clinical studies of deucrictibant for both the prophylactic and the on-demand treatment of HAE attacks.

(Source: Pharvaris)