According to clinicaltrials.gov under the U.S. National Institutes of Health, the EU Clinical Trials Register, and the International Clinical Trials Registry Platform under the World Health Organization (WHO), the following trials are currently or soon to be recruiting (as of 24 March 2026).
Read more about these and other clinical trials at:
Study Investigating the Effectiveness and Safety of Garadacimab for Treating Patients With Hereditary Angioedema (HAE)
Location(s): United States, Germany
Recruiting
https://clinicaltrials.gov/study/NCT07001280
STOP-HAE: A Phase 3 study of ADX-324 in HAE (STOP-HAE)
Location(s): United States, Canada, Czechia, Hungary, Spain
Recruiting
https://clinicaltrials.gov/study/NCT06960213
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
Location(s): TBC
Not yet recruiting
https://clinicaltrials.gov/study/NCT07428499
A Study Of Navenibart in Participants with Hereditary Angioedema
Location(s): United States, Australia, Brazil, Bulgaria, Canada, Czechia, France, Germany, Hong Kong, Hungary, Israel, Italy, Japan, Netherlands, New Zealand, North Macedonia, Poland, Puerto Rico, South Africa, South Korea, Spain, United Kingdom
Recruiting
https://www.clinicaltrials.gov/study/NCT06842823
HAE Burden and Crisis Management
Location(s): France
Recruiting
https://www.clinicaltrials.gov/study/NCT06806618
Safety Study in Subjects ≥ 12 Years of Age with Hereditary Angioedema Switching to Garadacimab
Location (s): United States, Canada, Germany
Recruiting
https://www.clinicaltrials.gov/study/NCT06806657
Suicide Ideation in Hereditary Angioedema
Locations: None provided
Not yet recruiting
https://www.clinicaltrials.gov/study/NCT06811467
Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema
Location(s): Argentina, Australia, Austria, Brazil, Bulgaria, Canada, Czechia, France, Germany, Hong Kong, Hungary, Israel, Italy, Japan, Netherlands, Poland, Puerto Rico, Saudi Arabia, South Africa, South Korea, Spain, Sweden, Türkiye, United Kingdom, United States
Enrolling by invitation
https://clinicaltrials.gov/study/NCT05396105
Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C-1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks
Location(s): United States, Albania, Argentina, Armenia, Bulgaria, Mexico, Montenegro, Peru, Romania, Serbia, Türkiye, Ukraine
Recruiting
https://www.clinicaltrials.gov/study/NCT06361537
Institutional Registry of Rare Diseases
Location(s): Argentina
Recruiting
https://www.clinicaltrials.gov/study/NCT06573723
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with HAE (CHAPTER-4)
Location(s): United States, Australia, Austria, Bulgaria, Canada, Germany, Hong Kong, Ireland, Italy, Poland, South Africa, South Korea, Spain, United Kingdom
Recruiting
https://www.clinicaltrials.gov/study/NCT026679881
Angioedema Biomarker Research Study
Locations: None provided
Unknown status
https://www.clinicaltrials.gov/study/NCT06210698
Identification and Characterization of Genetic Variants in Hereditary Angioedema (GENOMAEH_01)
Location(s): Spain
Not yet recruiting
https://www.clinicaltrials.gov/study/NCT05833620
Oral Deucrictibant for Prophylactic and Acute Treatment in Hereditary Angioedema Patients (BK-AE-nC1INH)
Location (s): United States
Recruiting
https://clinicaltrials.gov/study/NCT07046806
A Study About the Diagnosis and Management of Hereditary Angioedema (HAE) in Egypt (EXPLORHAE)
Location (s): Egypt
Not yet recruiting
https://clinicaltrials.gov/study/NCT07218393
A Study of Lanadelumab in Children With Hereditary Angioedema (HAE) in Multiple Countries
Location (s): Argentina, France, Germany, Israel, Serbia, United Kingdom
Recruiting
https://clinicaltrials.gov/study/NCT07251933
A Long-Term Study of Navenibart in Participants With Hereditary Angioedema
Location (s): United States
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT07204938
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies (APeX-A)
Location (s): Canada, Czechia, France, Germany, North Macedonia, Poland, Slovakia, South Africa, South Korea, Spain, United Kingdom
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT04933721
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in the Kingdom of Saudi Arabia
Location (s): Saudi Arabia
Not yet recruiting
https://clinicaltrials.gov/study/NCT07263685
Donidalorsen Treatment in Children With Hereditary Angioedema
Locations: United States
Recruiting
https://clinicaltrials.gov/study/NCT07298447
A Study to Learn About the C1-Inhibitor Function as Diagnosis for Hereditary Angioedema (AHAE)
Locations: Algeria
Not yet recruiting
https://clinicaltrials.gov/study/NCT07293364
Long-Term Follow-Up (LTFU) of Subjects Treated With NTLA 2002
Location (s): Australia, France, Germany, Netherlands, New Zealand, United Kingdom
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT06262399
Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency (CREAATE)
Location (s): United States, Canada, United Kingdom
Recruiting
https://clinicaltrials.gov/study/NCT07266805
A Study of Takhzyro in Teenagers and Adults With Hereditary Angioedema (HAE) in South Korea
Location (s): TBC
Recruiting
https://clinicaltrials.gov/study/NCT07445087
Real-life Ecological Momentary Assessment of Lived Burden in Hereditary AngioEdema (REAL-HAE)
Location (s): Italy
Recruiting
https://clinicaltrials.gov/study/NCT07448181