HAEi’s CEO and Chairman of the Board, Anthony J. Castaldo, and HAEi’s President, Henrik Balle Boysen

Dear HAEi Friends,

We are delighted to welcome you to the second 2025 edition of Global Perspectives – HAEi’s flagship magazine that shares what’s happening in the global HAEi community. Throughout the magazine, you will sense the shared determination of our worldwide HAEi family—people working side by side to bring earlier diagnosis, better care, and lasting change.

This issue is packed with updates from across our community that include:

  • Country-by-country reports from our RPAs across Europe, the Middle East, and Africa (EMEA), the Americas, and Asia-Pacific (APAC), along with a clear view of what’s next in each region.
  • Record-breaking hae day :-) participation. HAEi Friends logged 211,012,980 steps across 44 countries—a 17% rise over last year—alongside local awareness events that helped more people find their way to diagnosis and care.
  • A feature on LEAP 2025, where 18 students receive specialized advocacy and communication training and mentoring while completing projects designed to help their Member Organizations.
  • Real-world stories of people using HAE TrackR to organize attack and treatment records for clinic visits, and HAE Companion for safer travel—Emergency Cards in 44 languages, ACARE locations, and practical tips.
  • An overview of the US HAEA National Summit, where more than 1,400 people came together to fulfill the meeting’s theme of Embracing a Brighter Future. Sessions focused on disease education, advocating for access to HAE medicines, and ongoing research into new therapies.
  • An HAEi pilot program—the Member Organization Growth & Impact Workshop—launched in Latin America & Mexico. This hands-on meeting brought together leaders from South America and Mexico to set country-specific 12-month plans for increasing diagnosis, awareness, and access. If successful, we’ll conduct this workshop in other parts of the world.
  • An overview of the HAEi/HAEA-sponsored medical journal publication on HAE with normal C1-inhibitor that lays out the current evidence on genetic causes, diagnosis, and therapies.
  • Information about the HAE Insight Series in the Asia Pacific, where expert‑led educational videos are helping healthcare professionals suspect and diagnose HAE earlier.
  • HAEi’s growing presence at major medical congresses in Africa, that is strengthening patient networks and improving diagnosis rates.

You will also find a lot more information, including clinical trial updates, a roundup of HAE publications, Member Organization news from around the world, and travel guidance.

In addition, preparations are well underway for the 2025 HAEi Regional Conference EMEA, taking place in Rome, Italy, 10–12 October 2025. We are finalizing details for bringing together 650–700 friends from across the region to connect, exchange knowledge, and strengthen collaboration while enjoying one of Europe’s great cities.

The content of this Global Perspectives edition reflects a simple principle: Working together across regions, cultures, and experiences enhances the global HAE movement and inspires us to unite and help everyone in our community fulfill their life’s ambitions.

We are very happy that you are such an important part of the global HAE movement, and we wish you pleasant reading!

Warmest regards,

Anthony J. Castaldo


Chief Executive Officer and Chairman of the Board, HAE International (HAEi)

Henrik Balle Boysen


President, HAE International (HAEi)