From Mariam Movsisyan, HAE Armenia

A Milestone for Hereditary Angioedema Care in Armenia: First Successful Pregnancy in a Patient with HAE Type III.

Armenia has reached an important milestone in the management of hereditary angioedema (HAE) with the successful pregnancy and delivery of a healthy baby by a woman diagnosed with HAE type III—the first such documented case in the country.

The patient, a young woman with recurrent episodes of angioedema without C1-inhibitor deficiency, was diagnosed with HAE type III prior to pregnancy. Given the known challenges associated with hormonal influences on disease activity, pregnancy was initially considered high risk. However, following pre-pregnancy counseling and close multidisciplinary supervision, a carefully individualized management plan was developed.

Throughout pregnancy, the patient was regularly monitored by allergists-immunologists and obstetricians experienced in high-risk care. Emphasis was placed on prophylaxis, early recognition of symptoms, and preparedness for acute attacks. Importantly, treatment decisions were guided by international HAE recommendations and adapted to local clinical practice.

Despite the physiological and hormonal changes of pregnancy, the patient experienced no life-threatening attacks. Delivery was completed without complications, and both mother and newborn remained healthy in the postpartum period.

This case represents a significant achievement for HAE care in Armenia, demonstrating that with timely diagnosis, expert counseling, and coordinated care, women with HAE type III can safely plan pregnancy and achieve favorable outcomes. It also highlights the growing awareness and capacity for managing rare diseases in the region.

The Armenian HAE community hopes this experience will encourage earlier diagnosis, patient education, and confidence among women with HAE who wish to build families.