According to clinicaltrials.gov under the U.S. National Institutes of Health, the EU Clinical Trials Register, and the International Clinical Trials Registry Platform under the World Health Organization (WHO), the following trials are currently or soon to be recruiting (as of 5 January 2026).
Read more about these and other clinical trials at:
Study Investigating the Effectiveness and Safety of Garadacimab for Treating Patients With Hereditary Angioedema (HAE)
United States, Germany
Recruiting
https://clinicaltrials.gov/study/NCT07001280
STOP-HAE: A Phase 3 study of ADX-324 in HAE (STOP-HAE)
United States
Recruiting
https://clinicaltrials.gov/study/NCT06960213
A Study Observing US Patients With HAE Type I or II Who Take Icatibant to Treat Attacks
United States
Recruiting
https://clinicaltrials.gov/study/NCT07009262
A Study Of Navenibart in Participants with Hereditary Angioedema
United States, Bulgaria, Canada, Czechia, Germany, Hong Kong, Israel, Italy, Japan, Netherlands, North Macedonia, Poland, South Africa, Spain, United Kingdom
Recruiting
https://www.clinicaltrials.gov/study/NCT06842823
HAE Burden and Crisis Management
France
Recruiting
https://www.clinicaltrials.gov/study/NCT06806618
Safety Study in Subjects ≥ 12 Years of Age with Hereditary Angioedema Switching to Garadacimab
United States, Canada
Recruiting
https://www.clinicaltrials.gov/study/NCT06806657
A Phase 2 In Adult Subjects with Hereditary Angioedema
United States, China, Germany, Italy, Poland, Spain
Recruiting
https://www.clinicaltrials.gov/study/NCT06846398
Suicide Ideation in Hereditary Angioedema
Locations: None provided
Not yet recruiting
https://www.clinicaltrials.gov/study/NCT06811467
A Survey of Lanadelumab in Participants With Hereditary Angioedema
Japan
Recruiting
https://clinicaltrials.gov/study/NCT05397431
Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema
Bulgaria, Canada, Czechia, France, Germany, Hungary, Israel, Poland, Spain, United States
Enrolling by invitation
https://clinicaltrials.gov/study/NCT05396105
Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C-1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks
United States, Albania, Argentina, Armenia, Bulgaria, Mexico, Montenegro, Peru, Romania, Serbia, Türkiye, Ukraine
Recruiting
https://www.clinicaltrials.gov/study/NCT06361537
Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients
Australia
Recruiting
https://clinicaltrials.gov/study/NCT05691361
Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) with HAE Type I or II (KONFIDENT-KID)
United States, Canada, France, Germany, Israel, Italy, Japan
Recruiting
https://clinicaltrials.gov/study/NCT06467084
Institutional Registry of Rare Diseases
Argentina
Recruiting
https://www.clinicaltrials.gov/study/NCT06573723
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE (CHAPTER-3)
United States, Argentina, Brazil, Bulgaria, Canada, France, Germany, Hong Kong, Hungary, Ireland, Italy, Japan, New Zealand, Poland, Puerto Rico, Romania, Singapore, Slovakia, South Africa, South Korea, Spain, Switzerland, Türkiye, United Kingdom
Recruiting
https://www.clinicaltrials.gov/study/NCT06669754
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with HAE (CHAPTER-4)
United States, Australia, Austria, Bulgaria, Canada, Germany, Hong Kong, Ireland, Italy, Poland, South Africa, South Korea, Spain, United Kingdom
Recruiting
https://www.clinicaltrials.gov/study/NCT06679881
Angioedema Biomarker Research Study
No locations provided
Not yet recruiting
https://www.clinicaltrials.gov/study/NCT06210698
Identification and Characterization of Genetic Variants in Hereditary Angioedema (GENOMAEH_01)
Spain
Not yet recruiting
https://www.clinicaltrials.gov/study/NCT05833620
Oral Deucrictibant for Prophylactic and Acute Treatment in Hereditary Angioedema Patients (BK-AE-nC1INH)
United States
Recruiting
https://clinicaltrials.gov/study/NCT07046806
A Study About the Diagnosis and Management of Hereditary Angioedema (HAE) in Egypt (EXPLORHAE)
Egypt
Not yet recruiting
https://clinicaltrials.gov/study/NCT07218393
A Study of Lanadelumab in Children With Hereditary Angioedema (HAE) in Multiple Countries
TBC
Not yet recruiting
https://clinicaltrials.gov/study/NCT07251933
A Long-Term Study of Navenibart in Participants With Hereditary Angioedema
United States
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT07204938
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies (APeX-A)
Canada, Czechia, France, Germany, North Macedonia, Poland, Slovakia, South Africa, South Korea, Spain, United Kingdom
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT04933721
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in the Kingdom of Saudi Arabia
Saudi Arabia
Not yet recruiting
https://clinicaltrials.gov/study/NCT07263685
Donidalorsen Treatment in Children With Hereditary Angioedema
Locations: None provided
Not yet recruiting
https://clinicaltrials.gov/study/NCT07298447
A Study to Learn About the C1-Inhibitor Function as Diagnosis for Hereditary Angioedema (AHAE)
Locations: None provided
Not yet recruiting
https://clinicaltrials.gov/study/NCT07293364
Long-Term Follow-Up (LTFU) of Subjects Treated With NTLA 2002
Australia, France, Germany, Netherlands, New Zealand, United Kingdom
Enrolling by invitation only
https://clinicaltrials.gov/study/NCT06262399
Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency (CREAATE)
United States
Enrolling
https://clinicaltrials.gov/study/NCT07266805