According to clinicaltrials.gov under the U.S. National Institutes of Health, the EU Clinical Trials Register, and the International Clinical Trials Registry Platform under the World Health Organization (WHO), the following trials are currently or soon to be recruiting (as of 21 March 2025).
Read more about these and other clinical trials at:
HAELO: a Phase 3 Study to Evaluate NTLA-2002 in Participants with Hereditary Angioedema (HAE)
United States
https://clinicaltrials.gov/study/NCT06634420
A Study Of Navenibart in Participants with Hereditary Angioedema
United States
https://www.clinicaltrials.gov/study/NCT06842823
A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)
Belgium, Bulgaria, Canada, France, Germany, Israel, Italy, Netherlands, Poland, Puerto Rico, Spain, Turkey, United Kingdom, United States,
https://clinicaltrials.gov/study/NCT05392114
HAE Burden and Crisis Management
France – not yet recruiting
https://www.clinicaltrials.gov/study/NCT06806618
Safety Study in Subjects ≥ 12 Years of Age with Hereditary Angioedema Switching to Garadacimab
No sites confirmed
https://www.clinicaltrials.gov/study/NCT06806657
A Phase 2 In Adult Subjects with Hereditary Angioedema
United States, China, Germany – not yet recruiting
https://www.clinicaltrials.gov/study/NCT06846398
Suicide Ideation in Hereditary Angioedema (HAE-SAFE)
No sites confirmed
https://www.clinicaltrials.gov/study/NCT06811467
A Survey of Lanadelumab in Participants With Hereditary Angioedema
Japan
https://clinicaltrials.gov/study/NCT05397431
A Long-term Study of STAR-0215 in Participants With Hereditary Angioedema
United States, Canada
https://www.clinicaltrials.gov/study/NCT06007677
PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial
Australia, Austria, Bulgaria, France, Germany, Greece, Israel, Japan, Netherlands, New Zealand, Spain, United Kingdom, United States
https://clinicaltrials.gov/study/NCT05511922
Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema
Bulgaria, Canada, Czechia, France, Germany, Hungary, Israel, Poland, Spain, United States – enrolling by invitation
https://clinicaltrials.gov/study/NCT05396105
Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults with Hereditary Angioedema (RAPIDe-3)
United States, Puerto Rico
https://www.clinicaltrials.gov/study/NCT06343779
Status of Dental Care Practices in Patients With Hereditary Angioedema
France
https://clinicaltrials.gov/study/NCT05776784
Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C-1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks
United States, Armenia, Bulgaria, Mexico, Peru, Romania, Serbia, Ukraine
https://www.clinicaltrials.gov/study/NCT06361537
Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients
Australia
https://clinicaltrials.gov/study/NCT05691361
A Study of Lanadelumab (Takhzyro) and Icatibant (Firazyr) in Persons With HAE in China
China
https://clinicaltrials.gov/study/NCT06346899
Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) with HAE Type I or II (KONFIDENT-KID)
United States
https://clinicaltrials.gov/study/NCT06467084
Institutional Registry of Rare Diseases
Argentina
https://www.clinicaltrials.gov/study/NCT06573723
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE (CHAPTER-3)
United States, Hong Kong, Ireland, South Korea, United Kingdom -not yet recruiting
https://www.clinicaltrials.gov/study/NCT06669754
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with HAE (CHAPTER-4)
Hong Kong, United Kingdom – not yet recruiting
https://www.clinicaltrials.gov/study/NCT06679881
Angioedema Biomarker Research Study
No sites confirmed
https://www.clinicaltrials.gov/study/NCT06210698
Identification and Characterization of Genetic Variants in Hereditary Angioedema (GENOMAEH_01)
Spain – not yet recruiting
https://www.clinicaltrials.gov/study/NCT05833620